Endocrine Abstracts

Many feeding hormones that are produced by peripheral tissues depend in part or whole on their abilities to cross the blood–brain barrier (BBB) in order to access their CNS sites of action. Some of these hormones, such as leptin, are transported across the BBB by saturable transport systems. A hallmark of BBB saturable transport systems for regulatory substances is that they are themselves modulated by pathophysiological events. Leptin transport, for example, is decreased...